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live combined lactobacillus

Development stage: Unknown
Lead developer: 广东龙创基药业
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Topical

Overview

Live combined lactobacillus is a live biotherapeutic product developed by Guangdong Longchuangji Pharmaceutical for the treatment of bacterial vaginosis (BV). It consists of a combination of live Lactobacillus strains, typically including *Lactobacillus crispatus*, *Lactobacillus gasseri*, and *Lactobacillus jensenii*, which are the dominant species in a healthy vaginal microbiome. Upon vaginal administration, these bacteria colonize the vaginal mucosa and produce lactic acid, which lowers the vaginal pH to an acidic range (pH < 4.5). This environment, along with the production of hydrogen peroxide and bacteriocins, inhibits the growth of anaerobic pathogens such as *Gardnerella vaginalis* and *Atopobium vaginae*, thereby restoring microecological balance and alleviating symptoms of infection.

Brand names: Mei Tai
Other names: Live Combined Lactobacillus Vaginal Capsules活联合乳杆菌胶囊

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