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live double combined lactobacillus

Development stage: Unknown
Lead developer: 广东龙创基药业
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Vaginal

Overview

Live double combined lactobacillus is a vaginal live biotherapeutic product (LBP) being developed by Guangdong Longchuangji Pharmaceutical for the treatment of bacterial vaginosis (BV). The formulation consists of two specific strains of live Lactobacillus bacteria delivered via a vaginal capsule. Its mechanism of action involves the restoration of the normal vaginal microflora, which is typically dominated by lactobacilli in healthy women. By colonizing the vaginal epithelium, these bacteria produce lactic acid to maintain an acidic pH and generate antimicrobial substances like hydrogen peroxide, thereby inhibiting the overgrowth of anaerobic pathogens such as Gardnerella vaginalis associated with BV.

Other names: live double combined lactobacillus capsule (vaginal)阴道用活双联合乳杆菌胶囊

Targets

PRR (Pattern recognition receptors)BVAB (Bacterial vaginosis-associated bacteria)

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