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Liversil
- Development stage
- Unknown
- Lead developer
- ACECR Institute of Medicinal Plants
- Modality
- Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Liversil is a standardized herbal medicinal product developed by the Iranian Institute of Medicinal Plants (IMP). It is derived from the seeds of *Silybum marianum* (Milk Thistle) and is standardized to contain a specific concentration of silymarin, a complex of flavonolignans including silybin, silydianin, and silychristin. The drug is primarily used for its hepatoprotective properties in the treatment of liver ailments such as non-alcoholic fatty liver disease (NAFLD), toxic liver damage, and chronic inflammatory liver conditions like hepatitis and cirrhosis. Liversil functions by acting as a free radical scavenger, inhibiting lipid peroxidation, and enhancing protein synthesis in hepatocytes by stimulating RNA polymerase I, thereby promoting the repair and regeneration of liver tissue.
- Brand names
- Liversil
- Other names
- Silybum marianum extractSilymarin
02
Targets
Pol I (RNA polymerase I)NF-κB
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