Drug intelligence / Profile preview

Livrite

Development stage
Unknown
Lead developer
Medley Pharmaceuticals
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Livrite is an oral, fixed-dose combination nutraceutical product developed by Medley Pharmaceuticals for the support of liver health and the management of various liver disorders. It contains four active ingredients: silymarin (a botanical extract from milk thistle), selenomethionine (a bioavailable source of selenium), alpha lipoic acid, and N-acetylcysteine. Together, these components provide synergistic hepatoprotective, antioxidant, and anti-inflammatory effects. Silymarin helps protect liver cell membranes and stimulates ribosomal RNA synthesis, while N-acetylcysteine acts as a precursor to glutathione, a critical endogenous antioxidant. Alpha lipoic acid serves as a mitochondrial cofactor and regenerates other antioxidants, and selenomethionine supports the activity of selenium-dependent antioxidant enzymes like glutathione peroxidase. Livrite is approved and marketed as a dietary supplement for conditions such as alcoholic and non-alcoholic fatty liver disease, cirrhosis, jaundice, and general liver detoxification.

Brand names
Livrite
Other names
acetylcysteine + alpha lipoic acid + selenomethionine + silymarinsilymarin + L-selenomethionine + alpha lipoic acid + N-acetylcysteinesilymarin + selenomethionine + alpha lipoic acid + acetylcysteinesilymarin + selenomethionine + alpha lipoic acid + N-acetylcysteinesilymarin + selenomethionine + alpha-lipoic acid + N-acetylcysteine
02

Targets

Pol I (RNA polymerase I)GPX4 (Glutathione peroxidase 4)α-KGDH (Alpha-ketoglutarate dehydrogenase complex)PDH (Pyruvate dehydrogenase complex)

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