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Lixisenatide is a once-daily injectable peptide drug used to treat type 2 diabetes mellitus. It is a glucagon-like peptide-1 (GLP-1) receptor agonist, also known as an incretin mimetic. Lixisenatide works by stimulating the pancreas to secrete insulin in response to high blood glucose levels, decreasing glucagon secretion, and slowing gastric emptying. These actions help lower postprandial and fasting blood glucose levels and may contribute to weight loss. Lixisenatide is not indicated for type 1 diabetes or as a substitute for insulin in patients requiring insulin therapy. The drug was developed by Sanofi and is marketed under the brand names Adlyxin (US) and Lyxumia (EU).
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