Drug intelligence / Profile preview

LMN-101

Development stage
Phase 2
Lead developer
Lumen Bioscience
Modality
Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Oral
01

Overview

LMN-101 is an investigational, orally administered biologic developed by Lumen Bioscience for prevention of *Campylobacter jejuni* enteric disease and associated traveler’s diarrhea. The product consists of spray-dried, genetically engineered *Arthrospira platensis* biomass containing a VHH-derived single-domain antibody binding protein that binds and inhibits *C. jejuni* FlaA flagellin, thereby neutralizing a bacterial motility and virulence factor in the gastrointestinal tract. LMN-101 completed Phase 1 safety testing and a Phase 2 controlled human challenge study in healthy volunteers. ([cdn.clinicaltrials.gov](https://cdn.clinicaltrials.gov/large-docs/63/NCT04098263/Prot_000.pdf))

02

Targets

Flagellin

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