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LMY-272
- Development stage
- Preclinical
- Lead developer
- Luminary Therapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
LMY-272 is an autologous CAR-T cell therapy being developed by Luminary Therapeutics for the treatment of solid tumors. It utilizes a proprietary 'Split Co-Stim Dual CAR' platform, which is engineered to target two distinct antigens: Chondroitin Sulfate Proteoglycan 4 (CSPG4) and CD70. This dual-targeting approach is designed to enhance tumor specificity and overcome antigen escape, while the split co-stimulatory signaling architecture aims to improve T-cell persistence and reduce exhaustion within the immunosuppressive solid tumor microenvironment. The therapy is currently in preclinical development.
- Other names
- CSPG4-CD70-CAR-T cell therapy (Split Co-Stim Dual CAR)
02
Targets
CD70 (Cluster of Differentiation 70)CSPG4 (Chondroitin sulfate proteoglycan 4)
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