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LMY-921

Development stage: Preclinical
Lead developer: Luminary Therapeutics
Modality: Allogeneic CAR-T → CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Allogeneic iPSCs → iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies
Administration: Intravenous

Overview

LMY-921 is an allogeneic, universal CAR-T cell therapy under development by Luminary Therapeutics for the treatment of B-cell malignancies. It is designed as a "Gamma 2.0+" CAR-T product that targets three key antigens associated with B-cell cancers: B-cell activating factor receptor (BAFF-R), B-cell maturation antigen (BCMA), and Tumor necrosis factor receptor superfamily member 13B (TACI). The mechanism of action involves inhibition or modulation of these targets to eliminate malignant B cells. As of April 2025, LMY-921 remains in preclinical development and has not yet entered clinical trials[1][2][3][5].

Targets

TACI (Tumor necrosis factor receptor superfamily member 13B)TNFRSF13C (B-cell Activating Factor Receptor)BCMA (B-cell maturation antigen)

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