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LMY-922
- Development stage
- Phase 1
- Lead developer
- Luminary Therapeutics
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Vaccines & Immunotherapeutics, Gene Therapies
- Administration
- Intravenous
01
Overview
LMY-922 is an allogeneic, non-viral chimeric antigen receptor (CAR)-T cell therapy developed by Luminary Therapeutics. It is designed to target the B-cell activating factor receptor (BAFF-R), as well as BCMA (B-cell maturation antigen) and TACI (Tumor necrosis factor receptor superfamily member 13B), making it a multi-targeted CAR-T therapy. The drug acts through immunologic cytotoxicity and T lymphocyte replacement mechanisms, aiming to treat autoimmune diseases by depleting pathogenic B cells. Its primary development focus has been on autoimmune disorders such as systemic lupus erythematosus and lupus nephritis. The product utilizes a universal CAR-T platform referred to as Gamma 2.0+ CAR T.
- Other names
- LMY 922LMY922LMY-922
02
Targets
TNFRSF13C (B-cell Activating Factor Receptor)BCMA (B-cell maturation antigen)TACI (Tumor necrosis factor receptor superfamily member 13B)
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