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LNA-ASO dual construct
- Development stage
- Preclinical
- Lead developer
- Instituto de Salud Carlos III
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
LNA-ASO dual construct is a multitargeting antisense oligonucleotide (ASO) construct designed for the treatment of hepatitis B virus (HBV) infection [575]. Developed by the Vall d'Hebron Research Institute (VHIR) and the University of Barcelona, the construct consists of two biostable locked nucleic acid (LNA) ASOs linked together by a stimuli-responsive linker [575]. This linker is specifically cleaved by endogenous intracellular enzymes upon cellular entry, releasing both LNA-ASOs [575]. The released ASOs target hyper-conserved regions of the HBV genome, leading to the potent silencing of intracellular pregenomic RNA (pgRNA) and inhibition of viral replication [575].
- Other names
- multitargeting ASO-based constructmultitargeting ASO-based constructs
02
Targets
HBV RNA (Hepatitis B virus RNA)
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