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LNP-LinearDNA canine cancer vaccine
- Development stage
- Unknown
- Lead developer
- Applied DNA Sciences
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular
01
Overview
The LNP-LinearDNA canine cancer vaccine is a therapeutic DNA-based immunotherapy designed for the treatment of canine B-cell lymphoma. Developed by Applied DNA Sciences through its subsidiary LineaRx in partnership with EvviVax, the vaccine utilizes a proprietary cell-free, polymerase chain reaction (PCR)-based manufacturing platform called LinearDNA. This platform produces high-fidelity DNA sequences encoding the telomerase reverse transcriptase (TERT) protein, a biological target often overexpressed in malignant cells. The vaccine is encapsulated in lipid nanoparticles (LNPs), which facilitates delivery into cells via intramuscular administration without the requirement for electroporation. By delivering the genetic sequence for TERT, the vaccine aims to stimulate the dog's immune system to recognize and eliminate TERT-expressing cancer cells, potentially improving survival outcomes in advanced stages of lymphoma.
- Other names
- LinearDNA canine cancer vaccineLNP-LinearDNA TERT vaccineLineaRx canine cancer vaccine
02
Targets
TERT (Telomerase)
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