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lobeglitazone + empagliflozin + metformin
- Development stage
- Phase 1
- Lead developer
- Chong Kun Dang Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination drug in development for type 2 diabetes, composed of lobeglitazone (a thiazolidinedione/PARγ agonist), empagliflozin (an SGLT2 inhibitor), and metformin (an AMPK activator). This multi-modal therapy is designed to improve glycemic control by targeting insulin sensitivity, renal glucose reabsorption, and hepatic glucose production through three complementary mechanisms. Developed primarily by Chong Kun Dang Pharmaceutical, this product is undergoing clinical trials to evaluate its pharmacokinetics and safety following oral administration in healthy subjects and in the context of type 2 diabetes mellitus[1][3][7].
- Brand names
- CKD-383CKD383CKD 383
- Other names
- Lobeglitazone/D745/D150
02
Targets
SGLT2 (Sodium-glucose cotransporter protein subunit 2)PPARG (Peroxisome proliferator-activated receptor gamma)PRKAB1 (AMPK β1)
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