lodenoisine

Lodenosine (also known as 5’-fluoro-2’,5’-dideoxyadenosine) is an experimental nucleoside analog and small molecule designed as a chemically and enzymatically stable anti-HIV agent. It acts as a reverse transcriptase inhibitor by mimicking natural nucleosides and interfering with viral DNA synthesis. Lodenosine was developed to be resistant to degradation by adenosine deaminase due to the presence of fluorination at the sugar moiety. Preclinical studies showed antiviral activity against HIV; however, clinical development was halted after adverse events including liver and kidney toxicity were observed in early trials[8][1]. The compound is not approved for any indication.

Other names

5'-fluoro-2',5'-dideoxyadenosine2',5'-dideoxy-5'-fluoroadenosineadenosine, 2',5'-dideoxy-5'-fluoro-(2S,3S,5R)-5-(6-amino-9H-purin-9-yl)-2-(fluoromethyl)oxolan-3-ol