Lodotra

Lodotra is a modified-release (delayed-release) oral formulation of the corticosteroid prednisone. Developed by Mundipharma Research Limited and Horizon Pharma, it utilizes SkyePharma's proprietary GeoClock technology to provide a programmed lag time of approximately four hours after evening administration (typically at 10 p.m.). This timing ensures that the active glucocorticoid is released in the early morning hours (around 2 a.m.) to coincide with the peak of pro-inflammatory cytokines like IL-6, thereby more effectively managing morning stiffness and pain in patients with inflammatory conditions. It is indicated for the treatment of polymyalgia rheumatica, rheumatoid arthritis, and other inflammatory diseases.

Brand names

LodotraRAYOS

Other names

Modified-release prednisoneDelayed-release prednisoneMR prednisone