Drug intelligence / Profile preview

Lodrane 24D

Development stage
Unknown
Lead developer
Elite Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

**Lodrane 24D** is an extended-release combination pharmaceutical product containing **brompheniramine maleate** (12 mg), an antihistamine, and **pseudoephedrine sulfate** (or HCl), a nasal decongestant, formulated for once-daily dosing. It provides symptomatic relief from nasal congestion, runny nose, sneezing, itchy/watery eyes, and other upper respiratory symptoms associated with **allergic rhinitis**, **common cold**, **hay fever**, **seasonal/perennial allergies**, **vasomotor rhinitis**, and related conditions like sinusitis or flu. Brompheniramine blocks histamine H1 receptors to reduce allergic responses, while pseudoephedrine acts as an alpha-adrenergic agonist to vasoconstrict nasal blood vessels and decrease congestion. Developed using Elite Pharmaceuticals' controlled-release technology (e.g., bead systems for sustained delivery over 24 hours), it was launched around 2006 via partnerships like ECR Pharmaceuticals (Hi-Tech Pharmacal subsidiary) and is available as prescription/OTC capsules.[1][3][6][7][8][9]

Brand names
Lodrane 24DLodrane24DLodrane-24D
Other names
Lodrane 24 D ER CapsuleLodrane24 D ER CapsuleLodrane-24 D ER Capsule
02

Targets

ADRA1A (α1A)HRH1 (Histamine H1 Receptor)

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