Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
lofentanil
- Development stage
- Preclinical
- Lead developer
- Janssen Pharmaceutica
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous (experimental/clinical Research), Epidural/extradural (studied In Clinical Trials)[2]
01
Overview
Lofentanil is an extremely potent synthetic opioid analgesic and a structural analog of fentanyl. It is most similar to carfentanil but is considered slightly more potent. Lofentanil acts primarily as a full agonist at the μ-opioid receptor, producing profound analgesia and anesthesia. It also acts as a full agonist at the κ-opioid receptor. The drug has a long duration of action and high lipophilicity compared to other fentanyl analogs, which limits its practical use in clinical settings due to increased risk of side effects such as respiratory depression and rapid development of tolerance. Its main application today is in research on opioid receptors rather than clinical medicine[1][2][3][5].
- Other names
- lofentanyl3-methylcarfentanil3-methyl-4-carbomethoxyfentanyl
02
Targets
MOR (Mu opioid receptor)KOR (Kappa opioid receptor)
Beyond the preview
Go deeper on lofentanil.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on lofentanil.