Drug intelligence / Profile preview

Logidruf-S

Development stage
Unknown
Lead developer
Canixa Life Sciences
Modality
Small Molecules
Administration
Topical
01

Overview

Logidruf-S is a topical combination formulation containing coal tar (4.25% w/v) and salicylic acid (2% w/v). Developed by Canixa Life Sciences, it is indicated for the treatment of hyperproliferative and inflammatory scalp and skin conditions, including psoriasis, seborrheic dermatitis, and dandruff. Coal tar acts as a keratoplastic agent that slows down the rapid proliferation of epidermal keratinocytes, primarily through the activation of the aryl hydrocarbon receptor (AHR) and subsequent suppression of DNA synthesis. Salicylic acid serves as a keratolytic agent that softens and exfoliates the outer layer of the skin, facilitating the removal of scales and plaques. Together, these active ingredients work synergistically to reduce scaling, flaking, itching, and inflammation of the scalp.

Brand names
Logidruf-S
Other names
coal tar + salicylic acidcoal tar / salicylic acid
02

Targets

AHR (Aryl hydrocarbon receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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