Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Lolawest
- Development stage
- Unknown
- Lead developer
- Western Pharmaceutical Industries
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Lolawest is a hypoammoniemic agent containing the stable salt L-ornithine L-aspartate (LOLA), developed and marketed by Western Pharmaceutical Industries. It is indicated for the treatment of hyperammonemia associated with acute and chronic liver diseases, such as liver cirrhosis and hepatic encephalopathy. The drug functions by providing substrates for two key ammonia detoxification pathways: the urea cycle in the liver (via ornithine) and glutamine synthesis in the liver, muscle, and brain (via aspartate). By lowering blood ammonia levels, Lolawest helps mitigate the neurotoxic effects of ammonia in patients with severe liver impairment. It is available in both oral sachet and injectable ampoule formulations.
- Brand names
- Lolawest
- Other names
- L-ornithine L-aspartateLOLA
02
Targets
CPS1 (Carbamoyl phosphate synthetase I)GLUL (Glutamine synthetase)OTC (Ornithine carbamoyltransferase)
Beyond the preview
Go deeper on Lolawest.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lolawest.