Drug intelligence / Profile preview

lomardexamfetamine

Development stage
Unknown
Lead developer
Zevra Therapeutics
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

KP106 (lomardexamfetamine) is a novel **prodrug comprised of d-amphetamine and a ligand** developed for the treatment of **Attention Deficit/Hyperactivity Disorder (ADHD)**[1][7][13]. It is intended to be administered as a **proprietary oral film dosage form** leveraging PharmFilm drug delivery technology[3][5][15]. KP106 is designed to release d-amphetamine in a controlled manner, which preclinical and Phase 1 data suggest may result in improved pharmacokinetics, reduced side effects (such as weight loss and cardiovascular effects), and potentially **decreased risk of abuse** compared to existing amphetamine-based therapies (e.g., Vyvanse)[1][3][7][13]. The drug is created using KemPharm's Ligand Activated Therapy (LAT) platform.

Brand names
KP106KP-106KP 106
Other names
KP106KP-106KP 106lomardexamfetamine
02

Targets

NET (Norepinephrine Transporter)TAAR1 (Trace amine-associated receptor 1)DAT (Dopamine plasma membrane transport protein)

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