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Long PD-L1 peptide vaccine is an investigational 19-amino-acid peptide cancer vaccine derived from programmed cell death ligand 1 and comprising the sequence FMTYWHLLNAFTVTVPKDL. It is intended to elicit PD-L1-specific CD4-positive and CD8-positive T-cell responses against PD-L1-expressing immunosuppressive and malignant cells. In the completed Phase I-II MPN study NCT04051307, PD-L1Long was administered subcutaneously with Montanide ISA-51 as adjuvant as part of a dual-peptide vaccination regimen for mutation-positive polycythemia vera and essential thrombocythemia. ([cancer.gov](https://www.cancer.gov/publications/dictionaries/cancer-drug/def/long-pd-l1-peptide-vaccine))
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