longikaurin a

Longikaurin A is a natural ent-kaurane diterpenoid isolated from the medicinal plant *Isodon ternifolius*. It exhibits potent anti-cancer properties, specifically demonstrated in models of hepatocellular carcinoma (HCC). The compound's mechanism of action involves inducing G2/M phase cell cycle arrest by downregulating the E3 ubiquitin ligase S-phase kinase-associated protein 2 (Skp2), which subsequently leads to the stabilization and increased expression of the cyclin-dependent kinase inhibitor p21. Additionally, Longikaurin A triggers apoptosis through the accumulation of reactive oxygen species (ROS), which activates the JNK/c-Jun signaling pathway. Preclinical studies in SMMC-7721 xenograft models have shown significant tumor suppression with minimal organ-related toxicity, positioning it as a promising lead compound for the development of targeted liver cancer therapies.

Other names

Longikaurin A