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lonicera japonica
- Development stage
- Phase 4
- Lead developer
- Chinese Academy of Medical Sciences
- Administration
- Oral, Topical, Intranasal, Intratumoral
01
Overview
Lonicera japonica, commonly known as Japanese honeysuckle or Jinyinhua, is a prominent medicinal plant in Traditional Chinese Medicine (TCM) valued for its antipyretic, anti-inflammatory, and detoxifying properties. It contains a diverse array of bioactive compounds, including chlorogenic acid, flavonoids (such as luteoloside and lonicerin), and polysaccharides. Research indicates its potential in treating various conditions, including type 2 diabetes, acute lung injury, heart failure, and certain cancers (e.g., thyroid cancer and acute myeloid leukemia). Its mechanisms involve the modulation of inflammatory pathways (NF-κB, Keap1/Nrf2), oxidative stress (STAT3/PGC-1α), and gut microbiota. It is also widely used as a food-medicine resource and a natural preservative.
- Other names
- honeysuckleJapanese honeysuckleJinyinhua金银花Lonicerae japonicae flos
02
Targets
NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)CTNNB1 (Beta-catenin)LGALS3 (Galectin-3)NET (Norepinephrine Transporter)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)NF-κBPPAR (PPAR family)PPARGC1A (Peroxisome proliferator–activated receptor gamma coactivator 1-alpha)STAT3 (Signal Transducer and Activator of Transcription 3)
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