lophenol

Lophenol (also known as 4α-methyllathosterol) is a naturally occurring phytosterol and tetracyclic triterpenoid isolated from *Aloe vera* gel and other plant sources. It serves as a key metabolic intermediate in the biosynthesis of plant sterols and the mammalian Kandutsch-Russell pathway for cholesterol synthesis. Research indicates that lophenol acts as an agonist of peroxisome proliferator-activated receptors (PPARs), specifically PPAR-alpha and PPAR-gamma, which regulate lipid and glucose metabolism. In preclinical models, lophenol has demonstrated anti-diabetic, anti-obesity, and hepatoprotective properties, and it has been evaluated in in silico and in vitro studies for its potential to inhibit pancreatic lipase, aldose reductase, and dipeptidyl peptidase-IV (DPP-IV). Additionally, as a component of Aloe sterols, it has been studied in clinical trials for improving skin elasticity, barrier function, and reducing facial wrinkles.

Other names

4-methylcholest-7-en-3-ol4α-methyl-5α-cholest-7-en-3β-ol4α-methyllathosterolmethostenol