lopinavir + ritonavir + raltegravir

This is a combination of three antiretroviral drugs used in the treatment of HIV infection. Lopinavir and ritonavir are both protease inhibitors; ritonavir acts primarily as a pharmacokinetic enhancer, increasing the plasma concentration of lopinavir by inhibiting its metabolism via Cytochrome P450 3A4 (CYP3A4). Raltegravir is an integrase inhibitor that blocks the integration of viral DNA into the host genome, a critical step in HIV replication. This combination may be used in certain clinical scenarios to increase treatment options for patients with HIV, including those who are antiretroviral-naive or have specific clinical needs such as late-presenting pregnancy or intolerance to other regimens.

Brand names

Kaletra

Other names

lopinavir and ritonavir