Drug intelligence / Profile preview

lopinavir + ritonavir + ribavirin

Development stage
Unknown
Lead developer
AbbVie
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination of three antiviral drugs—lopinavir, ritonavir, and ribavirin—used together as an investigational therapy for viral infections such as COVID-19 and MERS-CoV. Lopinavir and ritonavir are both protease inhibitors; ritonavir acts primarily to boost the plasma levels of lopinavir by inhibiting its metabolism via cytochrome P450 3A4. Ribavirin is a guanosine analog with broad-spectrum antiviral activity that inhibits viral RNA synthesis. The combination has been studied in clinical trials for its potential to reduce viral load, shorten duration of symptoms, and improve outcomes in patients with mild to moderate COVID-19 when compared to standard care or dual therapy[1][2][3][5]. This regimen does not have a unique brand name or code name.

02

Targets

CYP3A4 (Cytochrome P450 3A4)RdRp (Coronavirus RNA-dependent RNA polymerase)Mpro (3C-like proteinase of SARS-CoV-2)PR (Progesterone receptor)

Beyond the preview

Go deeper on lopinavir + ritonavir + ribavirin.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on lopinavir + ritonavir + ribavirin.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call