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Drug intelligence / Profile preview
lorigerlimab
- Development stage
- Phase 2
- Lead developer
- MacroGenics
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Lorigerlimab is an investigational, bispecific monoclonal antibody designed to target both programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) on tumor-infiltrating lymphocytes. By binding to these immune checkpoint proteins, lorigerlimab inhibits their mediated downregulation of T-cell activation and proliferation, thereby enhancing antitumor immune responses. The drug is based on MacroGenics' DART (Dual-Affinity ReTargeting) platform and is being developed primarily for the treatment of metastatic castration-resistant prostate cancer (mCRPC), with additional studies in solid tumors. Lorigerlimab has demonstrated a manageable safety profile and encouraging antitumor activity in early-phase clinical trials.
- Other names
- PD-1 x CTLA-4 bispecific DART moleculePD1 x CTLA-4 bispecific DART moleculePD 1 x CTLA-4 bispecific DART molecule
02
Targets
CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)PDCD1 (Programmed cell death protein 1 receptor)
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