lornoxicam + meperidine

The combination of lornoxicam and meperidine (also known as pethidine) refers to the pharmacological agents evaluated in a clinical trial (NCT01543399) conducted by Ain Shams University for the management of acute renal colic. Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class that acts as a potent, non-selective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), thereby reducing prostaglandin synthesis and providing significant analgesic and anti-inflammatory effects. Meperidine is a synthetic opioid analgesic that primarily functions as an agonist at the mu-opioid receptor, providing central analgesia. In the referenced study, these agents were compared (with lornoxicam often administered alongside low-dose ketamine) to determine their relative efficacy in relieving the intense pain associated with acute renal colic in an emergency setting.

Other names

lornoxicam + pethidinelornoxicam + mepridinelornoxicam + mepridine-Ain Shams University-renal colic