Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
lorpiprazole
- Development stage
- Phase 2
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Lorpiprazole is a small molecule drug of the phenylpiperazine group, marketed under the brand name Normarex. It is classified as a serotonin antagonist and reuptake inhibitor (SARI), similar to trazodone and nefazodone. Lorpiprazole acts by antagonizing serotonin 5-HT2A and 5-HT2C receptors, alpha1 and alpha2 adrenergic receptors, H1 histaminergic receptors, and at higher doses inhibits the SERT (serotonin transporter). This pharmacological profile allows it to increase synaptic levels of serotonin as well as modulate norepinephrine and dopamine transmission. Lorpiprazole is primarily indicated for major depressive disorder but has also been marketed as an anxiolytic[1][2][3][4][5][7].
- Brand names
- Normarex
- Other names
- lorpiprazole
02
Targets
HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)ADRA1A (α1A)ADRA2A (α2A)HRH1 (Histamine H1 Receptor)SERT (Sodium-dependent serotonin transporter)
Beyond the preview
Go deeper on lorpiprazole.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on lorpiprazole.