Drug intelligence / Profile preview

losartan + metoprolol

Development stage
Unknown
Lead developer
DuPont
Modality
Small Molecules
Administration
Oral
01

Overview

Losartan + metoprolol is a combination of two antihypertensive agents used together to manage high blood pressure and certain heart conditions. Losartan is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, leading to vasodilation and reduced blood pressure. Metoprolol is a beta-adrenergic blocker (beta-blocker) that reduces heart rate, cardiac output, and the workload on the heart by blocking beta-1 adrenergic receptors in the heart. This combination may be prescribed for hypertension, cardiomyopathy, congestive heart failure, or other cardiovascular indications where dual blockade of these pathways provides additive benefit[1][6][7]. Both drugs are available as generics and are commonly co-prescribed but not typically formulated as a single fixed-dose combination tablet.

02

Targets

ADRB1 (β1)AGTR1 (Angiotensin II Type-1 receptor)

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