losartan + isosorbide mononitrate

This drug is a combination of two active pharmaceutical ingredients: losartan, an angiotensin II receptor blocker (ARB), and isosorbide mononitrate (ISMN), an organic nitrate. Losartan works by selectively blocking the binding of angiotensin II to the AT1 receptor, leading to vasodilation, reduced blood pressure, and decreased aldosterone secretion. Isosorbide mononitrate acts as a nitric oxide donor; it relaxes vascular smooth muscle predominantly in veins but also in arteries, reducing cardiac preload and afterload. The combination may be used experimentally or off-label for additive antihypertensive effects or management of certain cardiovascular conditions such as hypertension with coexisting angina pectoris. There are no widely marketed fixed-dose products containing both agents together; use would typically involve co-prescription of individual drugs[1][3][4].

Other names

losartan + ISMNlosartan and isosorbide mononitrate