losartan + spironolactone

Losartan + spironolactone is a combination of two antihypertensive agents used together in clinical practice, though not as a fixed-dose commercial product. Losartan is an angiotensin II receptor blocker (ARB) that lowers blood pressure by blocking the action of angiotensin II on its receptor, leading to vasodilation and reduced aldosterone secretion. Spironolactone is an aldosterone receptor antagonist (mineralocorticoid receptor antagonist) that acts as a potassium-sparing diuretic, reducing sodium reabsorption and water retention while conserving potassium. The combination has been studied for its effects in conditions such as diabetic nephropathy and heart failure; it may reduce proteinuria, improve cardiac autonomic function, and promote angiogenesis in certain settings. However, the use of both drugs together increases the risk of hyperkalemia due to their complementary mechanisms affecting potassium homeostasis[1][3][5]. Clinical studies suggest potential benefits for renal protection and cardiovascular outcomes but require careful monitoring.

Brand names

CozaarAldactone

Other names

losartan and spironolactonelosartan plus spironolactone