losartan carboxylic acid

Losartan carboxylic acid is the major active carboxylic acid metabolite of losartan and a **small-molecule angiotensin II receptor blocker**. It is formed in vivo after administration of losartan and contributes substantially to the antihypertensive effect by selectively antagonizing the angiotensin II type 1 receptor, thereby reducing vasoconstriction and aldosterone-mediated effects. The compound is commonly used as an analyte in pharmacokinetic, bioequivalence, and CYP2C9 phenotyping studies, and recent 2024 publications also identified it as an inhibitor of human succinyl-CoA:glutarate-CoA transferase in biochemical screening and structural studies, suggesting a possible repurposing lead for glutaric aciduria type 1. In the provided literature it is also discussed in exploratory ACE2-binding work and in environmental metabolism studies as a major transformation product of losartan.

Other names

losartan carboxylic acidlosartan acidlosartan active metabolite