lotilaner

Lotilaner is an ectoparasiticide of the isoxazoline class, used as a small molecule antiparasitic agent. It acts as a non-competitive antagonist of gamma-aminobutyric acid (GABA)-gated chloride channels, selectively targeting mites and certain insects. Inhibition of these channels causes spastic paralysis and death in target organisms such as *Demodex* mites, fleas, and ticks. Lotilaner was originally developed for veterinary use to treat flea and tick infestations in dogs and cats but has since been approved for human use as an ophthalmic solution (Xdemvy) for the treatment of *Demodex* blepharitis—the first FDA-approved therapy for this condition[2][3][7][8]. The S-enantiomer is the active form *in vivo*[2].

Brand names

XdemvyCredelioCredelio Cat

Other names

lotilaner ophthalmic solution