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Low MAC-The First Affiliated Hospital of Anhui Medical University
- Development stage
- Unknown
- Lead developer
- The First Affiliated Hospital, Anhui Medical University
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
Low MAC-The First Affiliated Hospital of Anhui Medical University refers to a specific treatment arm in a clinical trial (NCT04292561) evaluating the use of low-concentration sevoflurane anesthesia. Sevoflurane is a volatile, halogenated ether inhalational anesthetic used for the induction and maintenance of general anesthesia. In this trial, Low MAC (Minimum Alveolar Concentration) refers to a target concentration of approximately 0.8 MAC, which is being compared against higher concentrations to determine its effect on the incidence of postoperative delirium (POD) in elderly patients undergoing abdominal surgery. Sevoflurane acts as a positive allosteric modulator of GABA-A and glycine receptors and as an antagonist of NMDA receptors, resulting in central nervous system depression and anesthesia.
- Brand names
- UltaneSevoraneSojournPetane
- Other names
- Low MAC sevofluranesevoflurane
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)Glycine receptorGABAA (Gamma-aminobutyric acid receptor)
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