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lowbush blueberry
- Development stage
- Preclinical
- Lead developer
- Wyman's of Maine
- Modality
- Small Molecules
- Administration
- Oral, Intperitoneal
01
Overview
Lowbush blueberry (Vaccinium angustifolium), also known as wild blueberry, is a polyphenol-rich fruit native to North America. It is widely recognized for its high concentration of anthocyanins, which contribute to its potent antioxidant and anti-inflammatory properties. In preclinical research, lowbush blueberry extracts have demonstrated neuroprotective effects in models of cerebral ischemia/reperfusion injury by downregulating pro-inflammatory markers such as iNOS and TNF-alpha and upregulating protective microRNAs (miR-146a and miR-21). Additionally, it is investigated as a functional feed additive in veterinary medicine, specifically in poultry, to modulate the cecal microbiome and resistome, potentially serving as an alternative to traditional antibiotics.
- Other names
- Vaccinium angustifoliumwild blueberry
02
Targets
NOS2 (Nitric Oxide Synthase 2)TNFA (Tumor necrosis factor alpha (soluble))miR-146a (microRNA-146a)miR-21 (MicroRNA-21)
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