LOXL2 recombinant protein

LOXL2 recombinant protein is a laboratory-produced version of the lysyl oxidase-like 2 (LOXL2) enzyme, a copper-dependent amine oxidase that catalyzes the cross-linking of collagen and elastin in the extracellular matrix. In the context of pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF), research indicates that LOXL2 acts as a myokine secreted by skeletal muscle. Exogenous treatment with recombinant LOXL2 protein has been shown to promote pulmonary artery smooth muscle cell (PASMC) proliferation and downregulate the tumor suppressor p53 via the CNPY2 signaling axis, contributing to pulmonary vascular remodeling. While the protein itself is used as a research tool to model disease mechanisms, the LOXL2 signaling axis is considered a potential therapeutic target for inhibition in fibrotic and vascular diseases.

Other names

recombinant LOXL2recombinant human LOXL2 proteinlysyl oxidase-like 2 recombinant protein