loxoribine

Loxoribine is a synthetic guanine ribonucleotide analog and immunostimulant. It acts as a **selective agonist of Toll-like receptor 7 (TLR7)**, a pattern recognition receptor on immune cells. Activation of TLR7 by loxoribine leads to immune stimulation, including maturation and activation of dendritic cells, B cells, and natural killer cells, as well as increased production of cytokines (such as IL-12, IL-23, IL-27, and IL-10). In animal models, loxoribine has demonstrated **antitumor and antiviral activity**. It has undergone **phase I clinical trials in patients with advanced cancer**, and is also used as an immunological research tool to stimulate TLR7 pathways[1][2][3][4][5][7][9].

Other names

7-allyl-8-oxoguanosine7-Allyl-7,8-dihydro-8-oxoguanosine7-Allyl-78-dihydro-8-oxoguanosine7a8oGuoLoxoribinaLoxoribinumGuanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-