LP-44

**LP-44** is a synthetic small molecule drug that acts as a potent and selective full agonist at the **5-HT7 serotonin receptor** (Ki = 0.22 nM), exhibiting over 200-fold selectivity against 5-HT1A (Ki = 52.7 nM) and greater than 1,000-fold against 5-HT2A. It has been widely utilized in preclinical research to investigate the receptor's roles in brain functions such as sleep-wake regulation, stress responses, learning, memory, analgesia, and bladder function modulation, including anti-ulcerogenic effects and improvements in micturition in spinal cord injury models. No developer or primary clinical indication is specified, and it remains a research tool without approved therapeutic use.[1][3][5][7][8][9][11][13]

Other names

LP44LP-44LP 444-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride