LPCAT3 siRNA

LPCAT3 siRNA is a small interfering RNA designed to silence the expression of lysophosphatidylcholine acyltransferase 3 (LPCAT3). LPCAT3 is an enzyme that preferentially catalyzes the synthesis of unsaturated phosphatidylserine (PS) in the plasma membrane. In KRAS-mutant pancreatic cancer cells, mutant KRAS forms signaling platforms (nanoclusters) that selectively enrich unsaturated PS. By knocking down LPCAT3, the levels of polyunsaturated PS are depleted, leading to the mislocalization of mutant KRAS and the disruption of its oncogenic signaling, specifically the MAPK pathway. This mechanism inhibits tumor cell proliferation and colony formation. Research into LPCAT3 siRNA has been conducted by investigators at UTHealth Houston and The Scripps Research Institute as a strategy to target diverse KRAS mutants and address drug resistance.

Other names

LPCAT3 knockdownLPCAT-3 knockdownLPCAT 3 knockdownsiRNA targeting LPCAT3