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LPNP-p198
- Development stage
- Preclinical
- Modality
- Nanoparticles → Drug Delivery Systems, RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
LPNP-p198 is a preclinical nanoparticle-based therapeutic designed to treat pancreatic ductal adenocarcinoma (PDAC), particularly cases resistant to gemcitabine. It consists of a polymeric nanoparticle carrier system (LPNP), composed of LGA-modified polyethyleneimine (PEI) and polylactic-co-glycolic acid (pLGA), which delivers a miR-198 mimic. The mechanism of action involves the downregulation of Valosin-Containing Protein (VCP) by miR-198, which disrupts autophagy maturation and sensitizes cancer cells to chemotherapy. In orthotopic mouse models, LPNP-p198 has demonstrated the ability to reduce tumor burden and metastases when used in combination with gemcitabine.
- Other names
- LPNP-miR-198LPNP-miR198LPNP-miR 198LGA-PEI nanoparticle-miR-198
02
Targets
MELTF (Melanotransferrin)Valosin-containing protein (VCP) mRNA 3′ untranslated region
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