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LPRI-424
- Development stage
- Unknown
- Lead developer
- Chemo Group
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**LPRI-424** is a prolonged-release, fixed-dose combined oral hormonal contraceptive containing **dienogest** and **ethinylestradiol** in a 24 active-tablet/4 placebo-tablet regimen. Dienogest is a progestogen with antiandrogenic activity, while ethinylestradiol is an estrogen; together they suppress gonadotropin signaling and ovulation, alter cervical mucus, and produce endometrial changes that prevent pregnancy. The formulation was developed by Chemo Research and affiliated Insud Pharma/Exeltis organizations and has been studied in Phase III trials for oral contraception and for treatment of polycystic ovary syndrome-associated hirsutism. It has been marketed in Europe under brands including Kelsee and Kelzyn.
- Brand names
- Dienogest/Ethinylestradiol ExeltisKelseeKelzyn
- Other names
- dienogest + ethinyl estradioldienogest + ethinylestradioldienogest/ethinyl estradioldienogest/ethinylestradiol
02
Targets
ESR2 (ERβ)PR (Progesterone receptor)AR (Adrenergic receptors)ESR1 (ERα)
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