Drug intelligence / Profile preview

LPT14E2

Development stage
Unknown
Lead developer
Guangzhou Diqi Pharmaceuticals
Modality
Small Molecules
Administration
Intramuscular
01

Overview

LPT14E2 is a long-acting injectable (LAI) formulation of lurasidone, an atypical antipsychotic, developed by Guangzhou Diqi Pharmaceutical Technology. Utilizing the company's proprietary Long-acting Platform Technology (LPT), the drug is designed to provide sustained release of lurasidone, thereby improving medication adherence in patients with schizophrenia. Lurasidone exerts its therapeutic effects through a complex pharmacological profile, primarily acting as an antagonist at dopamine D2, serotonin 5-HT2A, and 5-HT7 receptors, while also serving as a partial agonist at the 5-HT1A receptor. This formulation aims to maintain therapeutic drug levels for an extended duration, reducing the burden of daily oral dosing and the risk of relapse associated with non-compliance.

Other names
Lurasidone long-acting injection
02

Targets

ADRA2C (α2C)HTR7 (5-hydroxytryptamine receptor 7)HTR2A (Serotonin receptor 5-HT2A)DRD2 (Dopamine D2 Receptor)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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