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LRP8-overexpression lentivirus
- Development stage
- Preclinical
- Lead developer
- Zhongshan Hospital, Fudan University
- Modality
- Gene Therapies
- Administration
- Intravenous, Subcutaneous
01
Overview
LRP8-overexpression lentivirus is a gene therapy research tool designed to upregulate the expression of the Low-density lipoprotein receptor-related protein 8 (LRP8) gene. LRP8 is a member of the low-density lipoprotein receptor (LDLR) family and plays a critical role in cholesterol endocytosis. In multiple myeloma (MM), LRP8 is identified as an oncogenic factor that facilitates the uptake of cholesterol from the microenvironment, thereby activating the cholesterol-dependent mTORC1 signaling pathway. This activation promotes tumor cell proliferation, survival, and migration while suppressing autophagy. The lentiviral vector, typically constructed using a Ubi-MCS-3FLAG-CBh-gcGFP-IRES-puromycin backbone, is used in preclinical studies to establish stable cell lines and xenograft mouse models to investigate the metabolic reprogramming of cancer cells and evaluate LRP8 as a potential therapeutic target.
- Other names
- LRP8-overexpressing lentivirusLRP-8-overexpressing lentivirusLRP 8-overexpressing lentivirus
02
Targets
LRP8 (Apolipoprotein E receptor 2)
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