LS-102

LS-102 is a **synthetic derivative of astragaloside IV**, a natural product from the traditional Chinese medicine Radix Astragali. It is a **selective inhibitor of the E3 ubiquitin ligase synoviolin (SYVN1)** and has demonstrated **anti-inflammatory and metabolic effects**. Preclinical studies show LS-102 can significantly inhibit the secretion of TNF-α and PAI-1 by adipose stem cells, reduce body weight gain, improve lipid profiles (HDL-C, LDL-C), lower glucose and urea levels, and ameliorate both adipose tissue inflammation and renal pathology in obesity-related nephropathy models. LS-102 has higher oral bioavailability and improved intestinal absorption compared to its parent compound, astragaloside IV, and demonstrates a favorable acute toxicity profile in animal studies (no mortality at up to 5000 mg/kg). Its mechanism involves modulation of inflammatory and fibrotic signaling pathways, including TGF-β1/Smad[1][2][3][5][7].