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LSI-202

Development stage: Preclinical
Lead developer: LipoSeuticals
Modality: Small Molecules
Administration: Intravenous

Overview

LSI-202 is an intravenous lipid-based reformulation of the microtubule-stabilizing agent paclitaxel, developed by LipoSeuticals for the treatment of various cancers. Paclitaxel, a member of the taxane family, exerts its antineoplastic effect by binding to the beta-subunit of tubulin, which promotes the assembly of microtubules and inhibits their disassembly. This stabilization interferes with the dynamic instability of microtubules necessary for mitotic spindle formation, leading to cell cycle arrest in the G2/M phase and subsequent programmed cell death (apoptosis). LSI-202 utilizes a proprietary delivery system designed to enhance the solubility and pharmacological profile of paclitaxel, potentially reducing the side effects associated with conventional formulations that require surfactants like Cremophor EL.

Other names: paclitaxel

Targets

TUBB (Tubulin (alpha and beta subunits))

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