LSN2941091

LSN2941091 is an active metabolite of taladegib, specifically the amide N-desmethyl derivative (also called LSN3185556 or M75)[1]. Taladegib is a small molecule Hedgehog pathway inhibitor being investigated for the treatment of advanced cancers such as basal cell carcinoma and small cell lung cancer[1][3]. LSN2941091 circulates as the free base in plasma following taladegib administration, representing a major metabolic product found in both toxicology and human pharmacokinetic studies[1]. The mechanism of action of LSN2941091 is presumed to be inhibition of the Hedgehog signaling pathway, targeting Smoothened receptor, mirroring taladegib’s activity[1][3].

Other names

amide N-desmethyl taladegibLSN3185556LSN-3185556LSN 3185556M75M-75M 75