LTβR agonist antibody

An LTβR agonist antibody is a type of monoclonal or bispecific antibody designed to bind and activate the lymphotoxin beta receptor (LTβR), a member of the tumor necrosis factor receptor superfamily (TNFRSF3). LTβR signaling plays a critical role in lymphoid organogenesis, the maintenance of secondary lymphoid organ architecture, and the regulation of tissue homeostasis. In oncology, LTβR agonist antibodies are developed to induce the formation of tertiary lymphoid structures (TLS) and high endothelial venules (HEVs) within the tumor microenvironment, thereby promoting immune cell infiltration (such as T cells, B cells, and dendritic cells) and enhancing the efficacy of cancer immunotherapies. In transplantation, LTβR agonism has been investigated for its potential to preserve fibroblastic reticular cell (FRC) homeostasis and promote transplant tolerance.

Other names

anti-LTBR agonist antibodyanti-LTβR agonist antibodyLTBR agonist antibodylymphotoxin beta receptor agonist antibodylymphotoxin-beta receptor agonist antibody