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LT-2003
- Development stage
- Unknown
- Lead developer
- LTT Bio-Pharma
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
LT-2003 (Nano-PGE1) is a drug delivery system (DDS) nanoformulation of prostaglandin E1 (PGE1) being developed by LTT Bio-Pharma in collaboration with Beijing Tide Pharmaceutical. It utilizes stealth-type polymeric nanoparticles designed to accumulate in vascular lesions and provide sustained release of the active ingredient. This formulation is intended to improve upon traditional lipo-PGE1 products by reducing the frequency of administration from daily injections to once every two weeks, while potentially enhancing efficacy through targeted delivery to damaged blood vessels. It is primarily being investigated for the treatment of peripheral arterial occlusive disease.
- Other names
- Nano-PGE1Nano-PGE-1Nano-PGE 1LT-2003/Nano-PGE1
02
Targets
PTGER4 (Prostaglandin E2 receptor EP4 subtype)PTGER3 (Prostaglandin E2 receptor EP3 subtype)PTGER2 (Prostaglandin E2 receptor EP2)
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