ltbr classical nfkb blocking peptide

The LTβR classical NFκB blocking peptide is a synthetic, cell-permeable peptide designed to selectively disrupt the canonical (classical) NF-κB signaling pathway downstream of the Lymphotoxin beta receptor (LTβR). LTβR is a member of the TNF receptor superfamily that uniquely activates both the classical (IKKβ/RelA) and non-canonical (NIK/IKKα/RelB) NF-κB pathways. This peptide typically incorporates a protein transduction domain (such as TAT or Antennapedia) fused to a sequence derived from the LTβR cytoplasmic tail that contains the TRAF2-binding motif (e.g., PIEET). By acting as a competitive inhibitor for TRAF2 recruitment to the receptor's intracellular domain, the peptide prevents the assembly of the signaling complex necessary for IKKβ activation and subsequent RelA translocation. It is primarily utilized as a research tool to isolate the physiological effects of classical NF-κB signaling from non-canonical signaling in contexts such as lymphoid tissue development, chronic inflammation, and tumor biology.

Other names

LTβR classical NFκB blocking peptideLTβR-derived classical NF-κB inhibitory peptideLymphotoxin beta receptor classical pathway blocking peptide