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LTC004 + regorafenib
- Development stage
- Unknown
- Lead developer
- Bayer
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
LTC004 + regorafenib is a combination therapy being developed by Beijing Zhidao Biological Technology Co., Ltd. for the treatment of metastatic colorectal cancer (mCRC). LTC004 is a biologic agent that acts as a dual Interleukin-2 receptor (IL-2R) and Interleukin-15 receptor (IL-15R) agonist, designed to stimulate immune cell proliferation and activity. Regorafenib (brand name Stivarga) is an oral multi-kinase inhibitor that targets multiple receptor tyrosine kinases involved in angiogenesis (VEGFR1-3, TIE2), oncogenesis (KIT, RET, BRAF), and metastasis (PDGFR-β, FGFR). The combination is currently in Phase II clinical development, evaluating the safety and preliminary efficacy in patients with mCRC who have failed standard treatments.
- Other names
- LTC004 + regorafenib
02
Targets
IL-2Rβγ (Interleukin-2 receptor subunit beta/common gamma chain complex)KIT (c-KIT proto-oncogene receptor tyrosine kinase)RAF (RAF family kinase)FGFR (FGFR family)TEK (Tie2)VEGFR3 (Vascular endothelial growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)RET (Rearranged during transfection receptor tyrosine kinase)PDGFRB (Platelet-derived growth factor receptor beta)
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